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KMID : 0350519930460020657
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Journal of Catholic Medical College
1993 Volume.46 No. 2 p.657 ~ p.665
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Effects of Verapamil and Hydralazine on Diuretic Action of Hydrochlorothiazide in Isolated Perfused Rabbit Kidney
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Abstract
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There has been controversy over diuretic effect of verapamil whether due to hemodynamic effect or inhibition of tubular reabsorption of water and sodium. Hydrochlorothiazide(HCTZ), the prototype of diuretics, is known to increase rebsorption of
calcium
at distal tubular cells, but relationship with diuretic effect of verapamil is not determined.
This study was undertaken to investigate the effects of verapamil and hydralazine on diuretic action of HCTZ in isolated perfused rabbit kidney.
@ES The results were as follows :
@EN 1. At a constant perfusion fllow rate, administration of verapamil and hydralazine increased the renal blood flow and decreased the renal vascular resistance significantly. However, the filtration fraction was decreased only in hydralazine
group
significantly.
2. The urine volume and electrolytes according to time interval were significantly increased in both verapamil and hydralazine groups compared to those in control group.
3. The pretreatment of verapamil or hydralazine showed the significant increase in urine volume and electrolytes compared to those in furosemide alone group.
4. Administration of HCTZ with the pretreatment of hydralazine showed the significant increase in urine volume and eletrolytes compared to those in HCTZ alone group. In contrast, the administration of HCTZ with the pretreatment of verapamil did
not
show the significant increase in urine volume and electrolytes compared to those in HCTZ alone group.
5. Based on urine volume and electrolytes of HCTZ alone group, hydralazine pretreament group showed the significant increasing effect of both parameters compared to those in verapamil pretreament group.
The results of this experiment demonstrate that verapamil does not potentiate the diuretic action of HCTZ at the renal distal tubule, while hydralazine potentiates the diuretic action of HCTZ.
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